Evolution of a Protein Interaction Domain Family by Tuning Conformational Flexibility
نویسندگان
چکیده
منابع مشابه
Evolution of a Protein Interaction Domain Family by Tuning Conformational Flexibility.
Conformational flexibility allows proteins to adopt multiple functionally important conformations but can also lead to nonfunctional structures. We analyzed the dynamic behavior of the enzyme guanylate kinase as it evolved into the GK protein interaction domain (GKPID) to investigate the role of flexibility in the evolution of new protein functions. We found that the ancestral enzyme is very fl...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2016
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.6b05954